Eukaryotic DNA replication

Eukaryotic DNA replication

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A cell's ability to control replication of its DNA is fundamental to its normal development or transformation into a cancerous state. DNA replication is also a crucial step in the cell cycle, and recent improvements in our understanding of cell cycle control have promoted a fresh surge ofinterest in the subject.This book begins with reviews of the molecular and genetic components of the replication machinery, and builds up a picture of how the replication process is regulated within the cell division cycle.4.2.2 Preventing rereplication The second question, how cells ensure that S phase itself occurs only once per cell cycle, has been ... Upon inactivation by high temperature, these alleles caused complete rereplication of the genome without intervening M phase, ... the Gl/S transition: it can be reset from G2 to Gl. If specific assembly of the mitotic form of the kinase is necessary to convey to the cell that it isanbsp;...

Title:Eukaryotic DNA replication
Author: J. Julian Blow
Publisher:Oxford University Press, USA - 1996-09-26

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